GOBBI, LUCA,RODRIGUEZ SARMIENTO, ROSA MARIA,WICHMANN, JUERGEN
申请号：
ES11728861
公开号：
ES2533063T3
申请日:
2011.07.04
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of the formula (I) ** Formula ** in which: X is O or S； Y is -C (O) - or -S (O) 2-； A is a single or double bond, provided that if X is S, then A is a double bond； R 1 is hydrogen, C 1-7 alkyl, C 1-7 haloalkyl, C 2-7 alkenyl, C 2-7 alkynyl, cycloalkyl, heterocycloalkyl, aryl, aryl fused with heterocycloalkyl, heteroaryl or -N (R 6) 2； said C1-7 alkyl, C1-7 haloalkyl, C2-7 alkenyl and C2-7 alkynyl are optionally substituted one to three times by independent R4； and said cycloalkyl, heterocycloalkyl, aryl, aryl fused with heterocycloalkyl and heteroaryl are optionally substituted one to three times by independent R5； R2, R3 are independently hydrogen, halogen, C1-7 alkyl, C1-7 haloalkyl, hydroxy, C1-7 alkoxy or C1-7 haloalkoxy； R4 is cyano, cycloalkyl, heterocycloalkyl, aryl, aryl fused with heterocycloalkyl, heteroaryl, -C (O) N (R6) 2, - N (R6) 2, -NH (CO) -C1-7 alkyl, hydroxy, C1 alkoxy -7, C1-7 haloalkoxy, oxo or -S (O) 2R7, said cycloalkyl, heterocycloalkyl, aryl, aryl fused with heterocycloalkyl and heteroaryl are optionally substituted one to three times by independent R5； R5 is halogen, cyano, C1-7 alkyl, C1-7 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -C (O) N (R6) 2, - N (R6) 2, -NH (CO) -C1 alkyl -7, hydroxy, C1-7 alkoxy, C1-7 haloalkoxy, oxo or -S (O) 2R7, said cycloalkyl, heterocycloalkyl, aryl and heteroaryl are optionally substituted one to three times by substituents independently selected from the group formed by halogen, cyano, C1-7 alkyl, C1-7 haloalkyl, hydroxy, alkoxy and oxo； R6 is hydrogen or C1-7 alkyl； R7 is hydrogen, C1-7 alkyl or aryl, said aryl is optionally substituted one to three times by substituents independently selected from the group consisting of halogen, cyano, C1-7 alkyl, C1-7 haloalkyl, hydroxy, C1- alkoxy 7, C1-7 haloalkoxy； and its pharmaceutically acceptable salts and esters； wherein the term "cycloalkyl" denotes a monovalent saturated monocyclic or bicyclic hydrocarbon radical of 3 to 8 ring atoms；
