As for this invention, formula (i) [in formula, as for R, hydroxy or NRR is R and R , in independence, hydrogen, low-grade alkyl, being shikuroarukiru mutually, or to be possible or the N atom which these have connected and becoming simultaneous and to form hetero alkyl ring R, the low-grade alkoxy which is substituted the low-grade alkyl which is substituted hydrogen, low-grade alkyl and the low-grade alkoxy, by halogen and halogen, by halogen, cyano or S (O) is - low-grade alkyl R is substituted) to be low-grade alkyl, - (CH) - aryl (with halogen with when, or - (CH) is - shikuroarukiru R and R is the low-grade alkyl which mutually is substituted to independence, by hydrogen or halogen or or - (CR) - aryl or - (CR) - hetero aryl (these rings) are may be substituted here with the substituent 1 or more it is selected from the low-grade alkoxy which is substituted low-grade alkyl and the cyano, hydroxy which are substituted halogen, low-grade alkyl, by halogen, by NRR or halogen, or are substituted) are - (CR) - shikuroarukiru (with hydroxy or aryl with when or, or hetero alkylIt is substituted) is ring (=O or - (CR) with - aryl with when, or or R and R the N atom which these have connected and becoming simultaneous, are substituted complex ring system (by low-grade alkyl, aryl or halogen substitution aryl with when) to be And as for R, to be possible to be the low-grade alkyl which mutually is substituted to independence, hydrogen, by low-grade alkyl or hydroxyl n is 1 or 2 m, 0, 1 or 2 is] chemical compound, or the pharmacy activity the salt and the racemic mixture, regards enanchioma, optical isomer or tautomerization isomer. As for this chemical compound, depression, painfully, the psychosis and the parkinsons disease, the integrated malfunction symptom, insecurity and note defective multi dynamic obstacles (ADHD) it was discovered that it is the promising NK 3 receptor antagonist for disposal.本発明は、式(I)[式中、R1は、ヒドロキシ又はNR’R”であり;R’及びR”は、相互に独立に、水素、低級アルキル、シクロアルキルで
