Lentiviral vectors for the preparation of immunotherapeutic compositions

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专利权人:

アンスティテュ・パストゥール;アンスティテュ・パストゥール;サーントル・ナシヨナル・ドゥ・ラ・ルシェルシェ・シヤンティフィック

发明人:

ピエール・シャルノー,ヒュセイン・フィラ,ベロニーク・ズノー

申请号：

JP2010251771

公开号：

JP5265643B2

申请日:

2010.11.10

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions being of retroviral or retroviral-like origin, said vector comprising in addition a defined nucleotide sequence (transgene or sequence of interest) and regulatory signals of retrotranscription, expression and encapsidation of retroviral or retroviral-like origin, wherein the composition is capable of inducing or of stimulating a cell-mediated response for instance a CTL (Cytotoxic T Lymphocytes) response or a CD4 response, against one or several epitopes encoded by the transgene sequence present in the vector.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/