Centre National de la Recherche Scientifique;Institut Pasteur
发明人:
Charneau, Pierre,Zennou, Veronique,Firat, Huseyin
申请号：
AU2010203111
公开号：
AU2010203111B2
申请日:
2010.07.21
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2010203111B220120119.pdf#####ABSTRACT The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions 5 being of retroviral or retroviral-like origin, said vector comprising in addition a defined nucleotide sequence (transgene or sequence of interest) and regulatory signals of retrotranscription, expression and encapsidation of retroviral or retroviral-like origin, wherein the composition is capable of inducing or of stimulating a cell-mediated response for instance a CTL (Cytotoxic T Lymphocytes) response or a CD4 response, D against one or several epitopes encoded by the transgene sequence present in the vector.
