Systems, methods and apparatus for substance dependence cessation management are described. The system involves an electronic mobile device, a communication network and a substance packet holder adapted with a substance packet dispenser, the substance packet holder connected to the electronic mobile device through the communication network. The system being capable of collecting user related information of a user for activating for an algorithm on the electronic mobile device based on the user related information, defining a plan for the cessation of substance dependence and capable of controlling a dispensing of a substance packet from the substance packet dispenser for the user.
