Stable, low viscosity antibody formulation

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专利权人:

MedImmune; LLC

发明人:

Bee, Jared,Santacroce, Paul,Du, Jiali,Dimitroca, Mariana

申请号：

AU2013334740

公开号：

AU2013334740A1

申请日:

2013.10.23

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

The present invention relates to a stable, low viscosity antibody formulation, wherein the formulation comprises a high concentration of anti-IL6 antibody. In some embodiments, the invention is directed to a stable, low viscosity antibody formulation comprising about 50 mg/mL to about 400 mg/mL of an anti-IL6 antibody, and arginine, wherein the antibody formulation is in an aqueous solution and has a viscosity of less than 20 cP at 23°C. Also provided are methods of making and methods of using such antibody formulations.

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