用於治療ＴＮＦα相關失調症之多重可變劑量療法农业专利-农业专业知识服务系统

发明人:: HOFFMAN, REBECCA S.,罗贝卡Ｓ　霍夫曼,羅貝卡Ｓ　霍夫曼,CHARTASH, ELLIOT K.,艾莉特Ｋ　柴特斯,TAYLOR, LORI K.,罗莉Ｋ　泰勒,羅莉Ｋ　泰勒,GRANNEMAN, GEORGE R.,乔治Ｒ　葛蓝曼,喬治Ｒ　葛藍曼,YAN, PHILIP,菲利浦　严,菲利浦　嚴,罗贝卡S 霍夫曼,羅貝卡S 霍夫曼,艾莉特K 柴特斯,罗莉K 泰勒,羅莉K 泰勒,乔治R 葛蓝曼,喬治R 葛藍曼,菲利浦严,菲利浦嚴

摘要：: Multiple-variable dose methods for treating TNFα-related disorders, including Crohn’s disease and psoriasis, comprising administering TNFα inhibitors, including TNFα antibodies, are described. Multiple-variable dose methods include administration of a TNF-inhibitor in an induction or loading phase followed by administration of the agent in a maintenance or treatment phase, wherein the TNF-inhibitor is administered in a higher dosage during the induction phase.本發明描述用於治療TNFα相關失調症(包括克隆氏病(Crohn's disease)及牛皮癬)之多重可變劑量方法，其包含投予TNFα抑制劑，包括TNFα抗體。多重可變劑量方法包括在誘導或負載期投予TNF抑制劑，接著在維持或治療期投予該藥劑，其中該TNF抑制劑係在誘導期間以較高劑量投予。