Multiple-variable dose methods for treating TNFα-related disorders, including Crohn’s disease and psoriasis, comprising administering TNFα inhibitors, including TNFα antibodies, are described. Multiple-variable dose methods include administration of a TNF-inhibitor in an induction or loading phase followed by administration of the agent in a maintenance or treatment phase, wherein the TNF-inhibitor is administered in a higher dosage during the induction phase.本發明描述用於治療TNFα相關失調症(包括克隆氏病(Crohns disease)及牛皮癬)之多重可變劑量方法,其包含投予TNFα抑制劑,包括TNFα抗體。多重可變劑量方法包括在誘導或負載期投予TNF抑制劑,接著在維持或治療期投予該藥劑,其中該TNF抑制劑係在誘導期間以較高劑量投予。
