用於治療TNFα相關失調症之多重可變劑量療法农业专利-农业专业知识服务系统

发明人:: HOFFMAN, REBECCA S.,霍夫曼　罗贝卡Ｓ,霍夫曼　羅貝卡Ｓ,CHARTASH, ELLIOT K.,柴特斯　莉特Ｋ,TAYLOR, LORI K.,泰勒　罗莉Ｋ,泰勒　羅莉Ｋ,GRANNEMAN, GEORGE R.,葛蓝曼　乔治Ｒ,葛藍曼　喬治Ｒ,YAN, PHILIP,严　菲利浦,嚴　菲利浦,霍夫曼罗贝卡S,霍夫曼羅貝卡S,柴特斯莉特K,泰勒罗莉K,泰勒羅莉K,葛蓝曼乔治R,葛藍曼喬治R,严菲利浦,嚴菲利浦

摘要：: Multiple-variable dose methods for treating TNFα-related disorders, including Crohn’s disease and psoriasis, comprising administering TNFα inhibitors, including TNFα antibodies, are described. Multiple-variable dose methods include administration of a TNF-inhibitor in an induction or loading phase followed by administration of the agent in a maintenance or treatment phase, wherein the TNF-inhibitor is administered in a higher dosage during the induction phase.本發明描述用於治療TNFα相關失調症(包括克隆氏病(Crohn's disease)及牛皮癬)之多重可變劑量方法，其包含投予TNFα抑制劑，包括TNFα抗體。多重可變劑量方法包括在誘導或負載期投予TNF抑制劑，接著在維持或治療期投予該藥劑，其中該TNF抑制劑係在誘導期間以較高劑量投予。