A surgery assistant system is provided for a surgeon to perform surgery on an affected region and comprises a surgery navigation device, an electronic device, a host and a head-mounted display device. The surgery navigation device continuously generates a simulated three-dimensional image signal related to a probe and the affected region and transmits the simulated three-dimensional image signal to a host. The electronic device generates a first indication message, displays the first indication message on a touch display panel, and receives a first feedback signal corresponding to the first indication message generated by the electronic device under operation so as to transmit the first feedback signal to the host. The host generates a first output message according to the simulated three-dimensional image signal and the first feedback signal.The head-mounted display device continuously receives the first output message and controls a lens to display the first output message.一種外科手術輔助系統,供醫師對患部進行手術時使用。一手術導航裝置連續產生一相關於一探針及該患部的模擬三維影像訊號且傳送至該主機。一電子裝置產生一第一指示訊息且顯示於一觸控顯示面板,且接受該電子裝置被操作而產生的一對應於該第一指示訊息的第一回饋訊號,將該第一回饋訊號傳送至該主機。該主機根據該模擬三維影像訊號及該第一回饋訊號產生一第一輸出訊息。一頭戴式顯示裝置持續接該第一輸出訊息,且控制一鏡片顯示該第一輸出訊息。100‧‧‧外科手術輔助系統1‧‧‧手術導航裝置11‧‧‧探針12‧‧‧通訊單元13‧‧‧處理單元2‧‧‧主機21‧‧‧網路單元22‧‧‧儲存單元23‧‧‧使用者輸入單元24‧‧‧處理單元3‧‧‧電子裝置31‧‧‧觸控顯示面板32‧‧‧通訊器33‧‧‧收音單元34‧‧‧控制器4‧‧‧影像擷取裝置5‧‧‧頭戴式顯示裝置51‧‧‧通訊模組52‧‧‧鏡片53‧‧‧影像擷取單元54‧‧‧錄音單元55‧‧‧處理模組61‧‧‧第一通訊網路62‧‧‧第二通訊網路7‧‧‧腦波儀