CID-NUNEZ, JOSE MARIA,OEHLRLCH, DANIEL,TRABANCO-SUAREZ, ANDRES AVELINO,TRESADERN, GARY JOHN,VEGA RAMIRO, JUAN ANTONIO,MACDONALD, GREGOR JAMES
申请号：
ES10721696
公开号：
ES2440001T3
申请日:
2010.05.11
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula (I) or a stereochemically isomeric form estedonde n is selected from the group consisting of 0, 1 and 2 m is selected from the group consisting of 0, 1, and 2 R is selected from methyl or trifluoromethyl R1 is selected from the group consisting of hydrogen 1-6 alkyl (1-3 alkyloxy) -C1-3 alkyl [(Alkyl C1-3oxi) C1-3 alkyloxy] C1-3alkyl C1-3alkyl substituted with one or more independently selected halo substituents unsubstituted phenyl unsubstituted benzyl benzyl substituted with 1, 2 or 3 substituents independently selected from the group consisting of halo, C1-3alkyl, oxy C 1-3 alkyl, C 1-3 alkyloxy C 1-3 alkyl, hydroxyC 1-3 alkyl, cyano, hydroxy, amino, C (> = O) R-, C (> = O) OR-, C (> = O) NR-R-, mono- or di (C 1-3 alkyl) amino, morpholinyl, (C 3-7 cycloalkyl) C 1-3 alkyloxy, trifluoromethyl and trifluoromethoxy where R- and R- are independently selected dehidrógeno and C1-6alkyl (Benzyloxy) C1-3alkyl unsubstituted C 3-7 cycloalkyl alquiloC1-3sustituido 3-7 cycloalkyl substituted with one or more independently selected halo substituents (C 3-7 cycloalkyl) C 1-3 alkyl, [(C 3-7 cycloalkyl) C 1-3 alkyloxy] C1-3alkyl (C 3-7 cycloalkyl) C 1-3 alkyloxy 4- (2,3,4,5-tetrahydrobenzo [f] [1,4] oxazepine) methyl Het1 Het1C1-3 alkyl Het2 and Het2C1-3 alkyl R2 is selected from the group consisting of cyano halo C1-3alkyl substituted with one or more substituents independently haloseleccionados 1-3 alkyloxy substituted with one or more substituents seleccionadosindependientemente halo C1-3alkyl 3-7 cycloalkyl and (C 3-7 cycloalkyl) C 1-3 alkyl.Un compuesto de fórmula (I) o una forma estereoquímicamente isomérica de estedonde n se selecciona del grupo que consiste en 0, 1 y 2 m se selecciona del grupo que consiste en 0, 1, y 2 R se selecciona de metilo o trifluorometilo R1 se selecciona del grupo que consiste en hidrógeno alquiloC1-6 (alquilC1-3oxi)-C1-3 alquilo [( alquil C1-3oxi)C1-3 alquiloxi]C1-3 alquilo C1-3 alquilo sustituido con uno o más sustituyente
