КОСГРОУВ Стефен Дэвид,ДЖОНЭЙТИС Дэвид Томас,САТЧ Джонатан Чарльз Деррик
申请号：
RU2013154741
公开号：
RU2013154741A
申请日:
2012.05.31
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. The co-crystals of the compound {1S- [1α, 2α, 3β (1S *, 2R *), 5β]} - 3- (7 - {[2- (3,4-difluorophenyl) cyclopropyl] amino} -5- (propylthio ) -3H-1,2,3-triazolo [4,5-d] pyrimidin-3-yl) -5- (2-hydroxyethoxy) cyclopentane-1,2-diol of formula (I) and cocrystal-forming molecule, wherein cocrystal-forming molecule is a acetylsalicylic kislotu.2. Cocrystal compound of formula (I) and acetylsalicylic acid according to claim 1, characterized in that it has an X-ray powder with peaks listed in the following Tablitsegde 2-theta values represent the values of +/- 0.2 ° .3 . Cocrystal compound of formula (I) and acetylsalicylic acid according to claim 2, characterized in that it has an X-ray powder with peaks, in addition to the peaks indicated in claim 2, which are indicated in the following Tablitsegde values of 2-theta They represent the values of +/- 0,2 ° .4. Cocrystal compound of formula (I) and acetylsalicylic acid according to any one of claims 1-3, characterized in that it has a stoichiometry of approximately 3: 2 Compound A: acetylsalicylic kislota.5. A method for producing co-crystals of the compound of formula (I) and acetylsalicylic acid according to claim 1, comprising mixing a suspension of the compound of formula (I) and acetylsalicylic acid in a suitable solvent such as dihlormetan.6. A method for producing co-crystals of the compound of formula (I) and acetylsalicylic acid according to claim 5, wherein a compound of formula III polymorph (I) .7. A pharmaceutical composition comprising the cocrystal compound of formula (I) and acetylsalicylic acid according to any one of claims 1-4 and a pharmaceutically acceptable diluent or nositel.8. Cocrystal compound of formula (I) and acetylsalicylic acid on a pleasure1. Сокристалл соединения {1S-[1α,2α,3β(1S*,2R*),5β]}-3-(7-{[2-(3,4-дифторфенил)циклопропил]амино}-5-(пропилтио)-3H-1,2,3-триазоло[4,5-d]пиримидин-3-ил)-5-(2-гидроксиэтокси)циклопентан-1,2-диол формулы (I) и сокристалл-образующей молекулы,где сокри
