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VACCINE COMPOSITION FOR COMBATING ECTOPARASIS INFECTIONS
专利权人:
СЕНТРО ДЕ ИНХЕНЬЕРИЯ ХЕНЕТИКА И БИОТЕКНОЛОХИЯ (CU)
发明人:
РОДРИГЕС МАЛЬОН Алина (CU),ФЕРНАНДЕС ДИАС Эрлинда (CU),ЭСТРАДА ГАРСИЯ Марио Пабло (CU),САРПИО ГОСАЛЕС Ямила (CU)
申请号:
RU2013119630/10
公开号:
RU2013119630A
申请日:
2011.09.26
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A vaccine composition for combating ectoparasite infections, containing the peptide of the ribosomal protein P0 of these ectoparasites, corresponding to the region between amino acids 267 and 301 of the protein. The composition of claim 1, wherein said peptide has an amino acid sequence identified as SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, SEQ ID NO: 9 or SEQ ID NO: 10, or is a fragment of these sequences, or a peptide or polypeptide having at least 70% identity with such sequences. 3. The composition according to claims 1 and 2, wherein the peptide is fused, conjugated or administered together with another molecule to increase their immunogenicity or enhance their protective effect. The composition of claim 3, wherein said molecule is selected from the group consisting of hemocyanin, a T-cell epitope from a tetanus toxin or a measles virus fusion protein, virus-forming particles, rabbit hemorrhagic disease virus, tick protein Bm86, tick protein Rs86 my32 sea lice or sea lice. 5. The composition according to claim 1, characterized by the effective control of infections by ticks and / or sea lice and / or the transfer of pathogens associated with them. The composition according to claims 1 and 2, wherein the peptide is prepared by recombinant methods or by chemical synthesis. The composition of claim 6, wherein the peptide obtained by recombinant methods is prepared using an expression system in yeast, bacteria, plants, insect larvae, insect cells or mammalian cells. The composition of claim 1, further comprising a vaccine adjuvant. The composition according to claims 1 and 2, where it is administered by injection in the range from 0.001 to 25 μg of the peptide / g of the mass of the vaccinated animal, using1. Вакцинная композиция для борьбы с заражениями эктопаразитами, содержащая пептид рибосомального белка P0 этих эктопаразитов, соответствующий области между аминокислотами 267 и 301 белка.2. Композиция по п.1, где указанный пептид имеет аминокислотную последо
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