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ANALOGUES OF 1-MENTILICOTINAMIDE
专利权人:
КОРТРИА КОРПОРЭЙШН (US)
发明人:
КРАНТЦ Александер (US)
申请号:
RU2010149896/04
公开号:
RU2010149896A
申请日:
2009.05.05
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A composition comprising at least one compound of formula (I) or formula (II)! ! where each R1 in each case of its presence is independently selected from the group consisting of H or D; ! R2 in each case of its presence is independently selected from the group consisting of H, D or CR1 3, provided that where there are two R2 substituents on the molecule, they are both not CR1 3; ! at least one of R1 or R2 is D; and! X-, when present, is a pharmaceutically acceptable counterion. ! 2. The compound according to claim 1, where X- is selected from the group consisting of chloride, bromide, benzoate, salicylate, acetate, citrate and lactate. ! 3. A method of treating or diagnosing a disease or disorder in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of a composition comprising at least one compound of formula (I) or formula (II)! ! where each R1 in each case of its presence is independently selected from the group consisting of H or D; ! R2 in each case of its presence is independently selected from the group consisting of H, D or CR1 3, provided that where there are two R2 substituents on the molecule, they are both not CR1 3; ! at least one of R1 or R2 is D; and! X-, when present, is a pharmaceutically acceptable counterion. ! 4. The method according to claim 3, where the specified disease or disorder is a heart disease, diabetes, cancer, osteoporosis, obesity, skin disorders, venous thrombosis, myocardial infarction, stroke, congestive heart failure, Alzheimer's disease, eczema, atherosclerosis, hyperlipidemia, hypertension1. Композиция, содержащая, по меньшей мере, одно соединение формулы (I) или формулы (II) ! ! где каждый R1 в каждом случае его присутствия независимо выбирают из группы, состоящей из H или D; ! R2 в каждом случае его присутствия независимо выбирают из группы, состоящей из H, D или CR1 3, при условии, что там, где на молекуле имеются два заместителя R2, они оба не являются CR1 3; ! п
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