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Azabicyclo [3.1.0] hexyl derivatives as modulators of D3 dopamine receptors
专利权人:
GLAXO GROUP LIMITED
发明人:
BERTANI, BARBARA,CREMONESI, SUSANNA,FONTANA, STEFANO,PASQUARELLO, ALESSANDRA
申请号:
ES08836651
公开号:
ES2378861T3
申请日:
2008.10.01
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of formula (I) 'or a salt thereof: ** Formula ** wherein G is selected from a group consisting of: phenyl, a 5- or 6-membered monocyclic heteroaryl group or an 8 to bicyclic heteroaryl group 11 members; p is an integer that varies from 0 to 5; R1 is halogen, hydroxy, cyano, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkanoyl and SF5; or corresponds to a group R6; and when p is an integer that varies from 2 to 5, each R1 can be the same or different; R2 is hydrogen or C1-4 alkyl; n is 3, 4, 5 or 6; R6 is a moiety selected from the group consisting of: isoxazolyl, -CH2-N-pyrrolyl, 1,1-dioxide-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2-pyrrolidinonyl, and said group R6 is optionally substituted with one or two substituents selected from: halogen, cyano, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 alkanoyl; R4 is selected from the group consisting of: hydrogen, halogen, hydroxy, cyano, C1-4 alkyl, C3-7 cycloalkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkanoyl and NR'R ''; or R4 is a phenyl group or a 5-14 membered heterocyclic group; and any of said phenyl or heterocyclic group is optionally substituted with 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 alkanoyl , C1-4 haloalkoxy and SF5; R7 is hydrogen or C1-2 alkyl; R 'is H, C1-4 alkyl or C1-4 alkanoyl; R '' is defined as R '; R 'and R' 'taken together with the interconnecting nitrogen atom can form a saturated or unsaturated, 5- or 6-membered heterocyclic ring.Un compuesto de fórmula (I)' o una sal del mismo: **Fórmula** en donde G se selecciona de un grupo que consiste en: fenilo, un grupo heteroarilo monocíclico de 5 o 6 miembros o un grupo heteroarilo bicíclico de 8 a 11 miembros; p es un número entero que varía de 0 a 5; R1 es halógeno, hidroxi, ciano, alquilo C1-4, haloalquilo C1-4, alcoxi C1-4, haloalcoxi C1-4, alcanoilo C1-4 y SF5; o corresponde a un grupo R6; y cuando p es un
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