As for this invention, the bioactive substance (especially, being water soluble, the bioactive substance of the high-molecular quantity) which possesses the action region inside the cell, non invasive by injection dosage, at the same time, it designates that the medicine composition for sutra colon absorption which it can deliver with high peculiarity is offered as purpose to inside the cell of organization of specification. The medicine composition for sutra colon absorption in this inventing at least below (a) and (b) features that it makes contain.(A) it possesses the action region inside the cell, at the same time, the bioactive substance which the lipo protein introduction substance connects(B) colon mucous membrane epithelium permeability of the aforementioned bioactive substance the chemical compound which possesses Shank action本発明は、細胞内に作用部位を有する生理活性物質(特に、水溶性で高分子量の生理活性物質)を、注射投与によらず非侵襲的に、且つ、特定の組織の細胞内へ高い特異性で送達し得る経大腸吸収用医薬組成物を提供することを目的とする。本発明における経大腸吸収用医薬組成物は、少なくとも以下の(a)及び(b)を含有させることを特徴とする。(a)細胞内に作用部位を有し、且つ、リポタンパク質導入物質が結合した生理活性物質;(b)前記生理活性物質の大腸粘膜上皮透過性亢進作用を有する化合物;
