As for this invention, the bioactive substance (especially, being water soluble, the bioactive substance of the high-molecular quantity) which possesses the action region inside the cell, non invasive by injection dosage, at the same time, it designates that the medicine composition for sutra colon absorption which it can deliver with high peculiarity is offered as purpose to inside the cell of organization of specification. The medicine composition for sutra colon absorption in this inventing at least below (a) and (b) features that it makes contain.(A) it possesses the action region inside the cell, at the same time, the bioactive substance which the lipo protein introduction substance connects(B) colon mucous membrane epithelium permeability of the aforementioned bioactive substance the chemical compound which possesses Shank action
