SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE;UNIVERSITÄT BASEL;VIROMETIX AG;UNIVERSITÄT ZÜRICH
发明人:
GHASPARIAN, Arin,ZUNIGA, Armando,GEIB, Nina,TAMBORINI, Marco,JUD, Maja,PLUSCHKE, Gerd,MARRERO NODARSE, Aniebrys,ROBINSON, John Anthony
申请号：
HK16113900.4
公开号：
HK1225739A
申请日:
2016.12.06
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid moiety, all covalently linked, which aggregate to synthetic virus-like particles. Proline-rich peptide antigens considered contain negatively and positively charged amino acid, and at least 15% of the amino acids are proline. Such synthetic virus-like particles carrying proline-rich antigens derived from pneumococcal proteins are useful as vaccines against infectious diseases caused by Gram-positive bacteria such as Streptococcus pneumoniae.
