Ho Taek IM,Taek Kwan KWON,Yong Il KIM,Jae Hyun PARK,Jong Soo WOO
申请号：
US14898935
公开号：
US20160367551A1
申请日:
2014.06.16
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to a complex granule formulation comprising a first granular part comprising levocetirizine or its pharmaceutically acceptable salt, cyclodextrin or its derivative, and an alkalinizing agent； and a second granular part comprising montelukast or its pharmaceutically acceptable salt, cyclodextrin or its derivative, and an alkalinizing agent. This formulation can effectively inhibit the production of related compounds of levocetirizine and montelukast by allowing levocetirizine and montelukast to form clathrate complexes with cyclodextrin, and using an alkalinizing agent. This formulation not only shows increased stability and bioavailability, but also improves patient compliance owing to its effective masking of bitter taste.
