UNIVERSITY OF MARYLAND, BALTIMORE;THE USA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS;BIOGEN CHESAPEAKE LLC
发明人:
SIMARD, J., Marc,JACOBSON, Sven
申请号：
HK18111842
公开号：
HK1252532A1
申请日:
2018.09.14
申请国别(地区):
HK
年份:
2019
代理人:
摘要：
Embodiments of the disclosure encompass methods and/or compositions for ameliorating or preventing intimal damage caused by mechanical stimulation of endothelial cells. The damage may be caused by use of a device within an artery, vein, or capillary of an individual, such as to remove a thrombus, an embolus or an atherosclerotic plaque in the vessel. Treatment and prevention embodiments concern therapeutically effective amounts of one or more antagonists of the SUR1-TRPM4 channel that is upregulated upon the mechanical stimulation.
