BIOGEN CHESAPEAKE LLC;UNIVERSITY OF MARYLAND BALTIMORE;THE USA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人:
申请号：
IL25587517
公开号：
IL255875D0
申请日:
2017.11.23
申请国别(地区):
IL
年份:
2018
代理人:
摘要：
Embodiments of the disclosure encompass methods and/or compositions for ameliorating or preventing intimal damage caused by mechanical stimulation of endothelial cells. The damage may be caused by use of a device within an artery, vein, or capillary of an individual, such as to remove a thrombus, an embolus or an atherosclerotic plaque in the vessel. Treatment and prevention embodiments concern therapeutically effective amounts of one or more antagonists of the SUR1-TRPM4 channel that is upregulated upon the mechanical stimulation.
