University of Maryland, Baltimore;The United States of America as Represented by the Department of Veterans Affairs;Biogen Chesapeake, LLC
发明人:
J. Marc Simard,Sven Jacobson
申请号：
US15577273
公开号：
US20180155727A1
申请日:
2016.05.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Embodiments of the disclosure encompass methods and/or compositions for ameliorating or preventing intimal damage caused by mechanical stimulation of endothelial cells. The damage may be caused by use of a device within an artery, vein, or capillary of an individual, such as to remove a thrombus, an embolus or an atherosclerotic plaque in the vessel. Treatment and prevention embodiments concern therapeutically effective amounts of one or more antagonists of the SUR1-TRPM4 channel that is upregulated upon the mechanical stimulation.
