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TGFP-CAP peptide and use thereof
专利权人:
ケアジェン シーオー エルティーディー
发明人:
チュン ヨンジ,キム ヨーンデグ,キム エゥンミ,チョイ ジュンヨーン,キム ジンセゥク,ソン サンス,チョ キョーンミ
申请号:
JP2010503955
公开号:
JP5378353B2
申请日:
2007.09.12
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-&bgr;1 (transforming growth factor-&bgr;1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-&bgr;1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-&bgr;1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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