Kyoung Mi Cho;Jin Seuk Kim;Yong-Ji Chung;Young Deug Kim;Jun Young Choi;Eun Mi Kim;Sang Su Song
发明人:
Yong-Ji Chung,Young Deug Kim,Eun Mi Kim,Jun Young Choi,Jin Seuk Kim,Sang Su Song,Kyoung Mi Cho
申请号：
US12596479
公开号：
US08969296B2
申请日:
2007.09.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to a GFP-CAP peptide having an amino acid sequence derived from TGF-β1 (transforming growth factor-β1) and a cell adhesion sequence, wherein the amino acid sequence derived from TGF-β1 consists of the amino acid sequence of SEQ ID NO:1 and the TGFP-CAP peptide is represented by the following formula I: Ile-Trp-Ser-Leu-Asp-Thr-Gln-Tyr-Cell adhesion sequence (I). The TGFP-CAP peptide of the present invention exhibits excellent anti-angiogenic activity. In addition, the TGFP-CAP peptide of the present invention prevents effectively melanin generation in skin to have skin whitening effects. The present peptide shows much higher stability and permeability to skin than natural-occurring TGF-β1. Such plausible activities and safety of the present peptide enable advantageously to application to drugs, quasi-drugs and cosmetics.
