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Alternaria peptide
专利权人:
サーカッシア リミテッド
发明人:
ハフナー、ロデリック ピーター,レイドラー、ポール,ヒッキー、パスカル,ラルシェ、マーク
申请号:
JP2015514589
公开号:
JP2015520771A
申请日:
2013.05.30
申请国别(地区):
JP
年份:
2015
代理人:
摘要:
A pharmaceutical preparation that may be used for the prevention or treatment of allergens against Alternaria and / or Cladosporium fungi, a pharmaceutically acceptable carrier or diluent, and at least three selected from the following: Pharmaceutical preparation containing peptide or pharmaceutically acceptable salt thereof: (a) polypeptide comprising amino acid sequence WSWKIGPAIATGNT (Alt28; SEQ ID NO: 101) or a T cell epitope-containing variant sequence derived from the amino acid sequence, or a salt thereof (b) Amino acid sequence KYRRVVRAGVKVAQTAR (Alt34A; SEQ ID NO: 107) or a polypeptide comprising a T cell epitope-containing mutant sequence derived from the amino acid sequence, or a salt thereof; (c) Amino acid sequence KYAGVFVSTGTLGGG (SEQ ID NO: 112 ) Or a polypeptide comprising a T cell epitope-containing variant sequence derived from the amino acid sequence, or a salt thereof; (d) amino acid sequence AEVYQKLKALAKKTYGQ (Alt13A; SEQ ID NO: 83) or A polypeptide comprising a T-cell epitope-containing variant sequence derived from an amino acid sequence, or a salt thereof; (e) comprising an amino acid sequence SLGFNIKATNGGTLD (Alt01A; SEQ ID NO: 60) or a T-cell epitope-containing variant sequence derived from the amino acid sequence (F) Amino acid sequence SAKRMKVAFKLDIEK (Alt06; SEQ ID NO: 72) or a polypeptide comprising a T cell epitope-containing mutant sequence derived from the amino acid sequence, or a salt thereof; (g) amino acid sequence DITYVATATLPNYCR (SEQ ID NO: 111) or a polypeptide comprising a T cell epitope-containing variant sequence derived from the amino acid sequence, or a salt thereof; and (h) the amino acid sequence GWGVMVSHRSGET (Alt14; SEQ ID NO: 84) or the amino acid sequence A polypeptide comprising a T cell epitope-containing variant sequence, or a salt thereof; wherein the T cell epitope-containing variant sequence of the amino acid sequence comprises up to 7 amino acid modifications An amino acid sequence having, each modification i
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