WHITTAMORE, PAUL ROBERT OWEN,SCOTT, JAMES STEWART,PACKER, MARTIN JOHN,STOCKER, ANDREW
申请号：
PE0000202012
公开号：
PE03552012A1
申请日:
2008.02.11
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a Derivative of pyrazole Compound of formula (1), where q is o, s or a simple Link r1 is alkyl of C1 - C6, alquenilo C2 - C6, alquinilo C2 - C6, among others R2 is cicloalquil C3 - C7 (CH2) m, policicloalquilc6 C12 - (CH2) m, Between other R3 is H, c1-c4 alkyl - ciclalquilo C3 C5, C3 cicloalquilmetilo - C5Among others, a is an optionally substituted phenyl or heteroaryl Ring with R10 and R11, R10 is c1-c4 alkyl, cyano, trifluoromethyl, Oh, Halo, among others R11 is C1 - C3 alkyl, optionally substituted with Fluorine X is a direct link, cicloalcandiilo cicloalcanilideno C3 - C4, C3 - C4, CH2O, between Other and it is a direct link, cicloalcandiilo cicloalcanilideno C3 - C4, C3 - C4Among others M is 0 to 2. Preferred compounds are: acid, 4 - [[4 - [(1S, 3R) - 5 - hydroxy - 2 - adamantil) Carbamoyl] - 5 - (propylsulfanyl pyrazol-1-yl] benzoic acid, 4 - [4 - (2 - adamantilcarbamoil) - 5 - (propylsulfanyl pyrazol-1-yl] benzoic acid acid, 4 - [4 - (4 - ilcarbamoil Oxan) - 5 - (propylsulfanyl pyrazol-1-yl] benzoic acid, among others. Refers to a Pharmaceutical Composition and a Preparation Process.These compounds are inhibitors of the Enzyme 11 beta hydroxysteroid dehydrogenase Type 1 (Human 11\u00dfhsd1) and are useful in the treatment of diseases related to metabolic syndromeREFERIDA A UN COMPUESTO DERIVADO DE PIRAZOL DE FORMULA (1), DONDE Q ES O, S O UN ENLACE SIMPLE R1 ES ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS R2 ES CICLOALQUIL C3-C7(CH2)m, POLICICLOALQUILC6-C12(CH2)m, ENTRE OTROS R3 ES H, ALQUILO C1-C4-CICLALQUILO C3-C5, CICLOALQUILMETILO C3-C5, ENTRE OTROS A ES UN ANILLO FENILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS CON R10 O R11 R10 ES ALQUILO C1-C4, OH, CIANO, TRIFLUOROMETILO, HALO, ENTRE OTROS R11 ES ALQUILO C1-C3 OPCIONALMENTE SUSTITUIDO CON FLUOR X ES UN ENLACE DIRECTO, CICLOALCANDIILO C3-C4, CICLOALCANILIDENO C3-C4, CH2O, ENTRE OTROS Y ES UN ENLACE DIRECTO, CICLOALCANDIILO C3-C4, CICLOALCANILIDENO C3-C4, ENTRE OTROS m ES 0 A
