THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
MASCOLA, JOHN R.,BOYINGTON, JEFFREY C.,YASSINE, HADI M.,KWONG, PETER D.,GRAHAM, BARNEY S.,KANEKIYO, MASARU
申请号：
CA2950085
公开号：
CA2950085A1
申请日:
2015.05.27
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
