MASCOLA JOHN R,BOYINGTON JEFFREY C,YASSINE HADI M,KWONG PETER D,GRAHAM BARNEY S,KANEKIYO MASARU
申请号：
IN201617042607
公开号：
IN201617042607A
申请日:
2016.12.14
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
Vaccines that elicit broadly protective anti influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g. ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self assemble to form the HA displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins and nucleic acid molecules encoding such proteins and assays using nanoparticles of the invention to detect anti influenza antibodies.
