John R. MASCOLA,Jeffrey C. BOYINGTON,Hadi M. YASSINE,Peter D. KWONG,Barney S. GRAHAM,Masaru KANEKIYO
申请号：
US15313265
公开号：
US20170202946A1
申请日:
2015.05.27
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Vaccines that elicit broadly protective anti-influenza antibodies. Some vaccines comprise nanoparticles that display HA trimers from influenza virus on their surface. The nanoparticles are fusion proteins comprising a monomeric subunit (e.g., ferritin) joined to the stem region of an influenza HA protein. The fusion proteins self-assemble to form the HA-displaying nanoparticles. The vaccines comprise only the stem region of an influenza HA protein joined to a trimerization domain. Also provided are fusion proteins, and nucleic acid molecules encoding such proteins, and assays using nanoparticles of the invention to detect anti-influenza antibodies.
