The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.本發明提供調節硬脂醯CoA去飽和酶活性之雜環衍生物。亦涵蓋使用該等衍生物來調節硬脂醯CoA去飽和酶活性之方法及包含該等衍生物之醫藥組合物。