The present invention relates to o-phenoxy and o-benzyloxypropylamino derivatives having pharmacological activity towards the α2δ□subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.本發明係關於具有針對電壓閘控鈣通道之α2δ子單元(尤其α2δ-1子單元)之藥理學活性的鄰苯氧基及鄰苄氧基丙胺基衍生物,製備此類化合物之方法,包含其之醫藥組合物,及其在療法中之用途,尤其用於治療疼痛。