The disclosure relates to Compounds of Formula (I)and pharmaceutically acceptable derivatives thereof, where R1, R4, R8, R9, and m are as defined herein, compositions comprising an effective amount of a Compound of Formula (I) or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, pain associated with osteoarthritis, osteoarthritis, UI, an ulcer, IBD, and IBS, comprising administering to an animal in need thereof an effective amount of a Compound of Formula (I) or a pharmaceutically acceptable derivative thereof.本發明關於式(I)化合物及其藥學上可接受之衍生物，其中R1、R4、R8、R9和m係如本文所定義，包含有效量之式(I)化合物或其藥學上可接受之衍生物的組成物，及治療或預防諸如疼痛、與骨關節炎相關的疼痛、骨關節炎、UI(尿失禁)、潰瘍、IBD(發炎性腸疾病)和IBS(躁性腸症候群)的病況之方法，其包含將有效量之式(I)化合物或其藥學上可接受之衍生物投予有需要之動物。
