The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.本發明係提供會調制硬脂醯基-CoA去飽和酶活性之雜環族衍生物。使用此種衍生物以調制硬脂醯基-CoA去飽和酶活性之方法,及包含此種衍生物之醫藥組合物亦被涵蓋在內。