PROCEDE POUR LA PREPARATION D'APOLIPOPROTEINE A-1 (APO A-1)

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专利权人:

CSL LIMITED

发明人:

VUCICA, YVONNE,WARREN, GARY LEE

申请号：

EP14808213

公开号：

EP3004160A4

申请日:

2014.06.05

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The present invention relates to processes of obtaining Apo A-1 from an Apo A-1 containing protein fraction (A), comprising suspending—the Apo A-1 containing protein fraction (A) in a buffer solution (B), removing impurities from the suspension while keeping the Apo A-1 proteins solubilized, followed by precipitating Apo A˜I from the suspension and collecting the Apo A-1 precipitate. Apo A-I obtained by such processes, reconstituted HDL obtained from such Apo A-1, and pharmaceutical compositions comprising such Apo A-I and/or reconstituted HDL also are provided.

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