Process for preparing apolipoprotein A-1 (Apo A-1)

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专利权人:

CSL Limited

发明人:

Vucica, Yvonne,Warren, Gary Lee

申请号：

AU2014277617

公开号：

AU2014277617A1

申请日:

2014.06.05

申请国别(地区):

AU

年份:

2015

代理人:

摘要：

The present invention relates to processes of obtaining Apo A-1 from an Apo A-1 containing protein fraction (A), comprising suspending- the Apo A-1 containing protein fraction (A) in a buffer solution (B), removing impurities from the suspension while keeping the Apo A- 1 proteins solubilized, followed by precipitating Apo A~ I from the suspension and collecting the Apo A-l precipitate. Apo A-I obtained by such processes, reconstituted HDL obtained from such Apo A-1, and pharmaceutical compositions comprising such Apo A-I and/or reconstituted HDL also are provided.

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