A pharmaceutical composition for treating an ischemic tissue, comprising: a core component and a matrix component, wherein the core component includes a thrombolytic drug and the matrix component includes a hyaluronan or derivative thereof, the matrix component having a viscosity greater than 10 mPa.s.一種用於治療組織缺血的醫藥組合物,包含一核心成分和一基質成分,其中所述核心成分包括溶栓藥物,並且所述基質成分包括透明質酸或其衍生物,所述基質成分的黏度大於10mPa.s。