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Tetrazole derivatives and their use as modulators of potassium channels
专利权人:
Saniona A/S
发明人:
DEMNITZ, Joachim,JORGENSEN, Susanne
申请号:
ES13731350
公开号:
ES2691270T3
申请日:
2013.06.25
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A tetrazole derivative of the general formula (I): ** Formula ** in which: - X is chosen to be hydrogen, halogen, hydroxy, cyano, C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 alkoxy ; and - Y is chosen to be hydrogen, halogen, cyano, hydroxy, amino, carbamoyl, formyl, acetyl, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 cyanoalkyl, C1-C6 cyanoalkoxy, C1-C6 hydroxyalkyl, C1-C6 hydroxyalkoxy, C1-C6 thioalkoxy, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, C3-C7 cycloalkyl, C3-C7-cycloalkyl-C1-C6-alkoxy, C1-C6 -alkoxy-C1-C6-alkoxy, C1-C6-alkoxy-carbonyl-C1-C6-alkoxy, acetyl-C1-C6-alkoxy, N, N-di-C1-C6-alkylamino, N- (N, N- di-C1-C6-alkylamino) -C1-C6-alkylamino, N-C1-C6-alkyl-carbonyl-amino, N- (C1-C6-alkoxy-C1-C6-alkyl) -amino, N, N-di -C1-C6-alkylamino-C1-C6-alkoxy, N-C1-C6-alkylsulfonyl-amino, N, N-di-C1-C6-sulfonyl-amino, amino-carbonyl-C1-C6-alkoxy, hydroxylamine-C1 -C6-alkylidene, benzyl or benzamide; as well as pharmaceutically acceptable salts thereof and / or their possible stereoisomers.Un derivado del tetrazol de fórmula general (I): **Fórmula** en la cual: - X se elige de forma que sea hidrógeno, halógeno, hidroxi, ciano, alquilo C1-C6, haloalquilo C1-C6 o alcoxi C1-C6; y - Y se elige de forma que sea hidrógeno, halógeno, ciano, hidroxi, amino, carbamoílo, formilo, acetilo, alquilo C1-C6, alcoxi C1-C6, haloalquilo C1-C6, haloalcoxi C1-C6, cianoalquilo C1-C6, cianoalcoxi C1-C6, hidroxialquilo C1-C6,hidroxialcoxi C1-C6, tioalcoxi C1-C6, alquilsulfinilo C1-C6, alquilsulfonilo C1-C6, cicloalquilo C3-C7, C3-C7-cicloalquil-C1-C6-alcoxi, C1-C6-alcoxi-C1-C6-alcoxi, C1-C6-alcoxi-carbonil-C1-C6-alcoxi, acetil-C1-C6-alcoxi, N,N-di-C1-C6-alquilamino, N-(N,N-di-C1-C6-alquilamino)-C1-C6-alquilamino, N-C1-C6-alquil-carbonil-amino, N-(C1-C6-alcoxi-C1-C6-alquil)-amino, N,N-di-C1-C6-alquilamino-C1-C6-alcoxi, N-C1-C6-alquilsulfonil-amino, N,N-di-C1-C6-sulfonil-amino, amino-carbonil-C1-C6-alcoxi, hidroxilamina-C1-C6-alquilideno, bencilo o benzamida; así como sales
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