PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING LIVER DISEASES COMPRISING CROMOLYN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT
The present invention relates to a pharmaceutical composition for preventing and treating liver diseases comprising cromolyn or a pharmaceutically acceptable salt thereof as an active ingredient. Cromolyn inhibits accumulation of collagen known as a main secretion marker of hepatic stellate cells (HSC) and production of TGF-&beta. In addition, cromolyn inhibits transfer of hepatocytes caused by the treatment with TGF-&beta in hepatocytes, suppresses a decrease in expression of E-cadherin caused by the progress of EMT, and has an anti-aging effect of hepatocytes. Thus, cromolyn has a double effect including an effect of inhibiting the activity of HSC cells and an effect of restoring the function of hepatocytes, and thus can be used advisably as a fundamental agent for treating various liver diseases, including liver cirrhosis.COPYRIGHT KIPO 2017
