CHILDRENS NATIONAL MEDICAL CENTER;CHILDREN'S RESEARCH INSTITUTE; CHILDREN'S NATIONAL MEDICAL CENTER;CHILDRENS RESEARCH INSTITUTE
发明人:
LIU, YANG,WANG, YIN
申请号：
CA2995582
公开号：
CA2995582A1
申请日:
2016.08.18
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
A method of preventing the development of GvHD or reducing the severity of GvHD in a mammalian subject receiving an allogeneic hematopoietic stem cell (HSC) transplant includes administering to the subject a pharmaceutical composition comprising an active agent that inhibits the biological activity or expression of hypoxia-inducible factor -la (HIF-la) or hypoxia-inducible factor -2a (HIF-2a), wherein the active agent is administered in an amount effective for preventing or reducing the severity GvHD in the subject.
