Alkyl derivatives of 1-oxa-4,9-diazospirondecane compounds with multimodal anti pain activity农业专利-农业学术服务平台

发明人:: VIRGILIBERNADO, Marina,玛丽娜．比尔希利贝尔纳多,瑪麗娜．比爾希利貝爾納多,ALONSOXALMA, Monica,莫妮卡．阿隆索哈尔马,莫妮卡．阿隆索哈爾馬,ALEGRETMOLINA, Carlos,卡洛斯．阿莱格雷特莫利纳,卡洛斯．阿萊格雷特莫利納,ALMANSAROSALES, Carmen,卡门．阿尔曼萨罗萨莱斯,卡門．阿爾曼薩羅薩萊斯,GARCIA LOPEZ,

摘要：: The present invention relates to compounds having dual pharmacological activity against sigma (σ) receptors and μ - opioid receptors, and more specifically to diazospirondecane compounds having such pharmacological activities； methods for preparing such compounds； pharmaceutical compositions containing them； and their use in therapy, in particular, in the treatment of pain.本發明涉及具有針對西格馬(σ)受體及μ‑類鴉片受體的雙重藥理學活性的化合物，並且更具體地，涉及具有此藥理學活性的二氮雜螺十一烷化合物；此類化合物的製備方法；包含它們的藥物組合物；及它們在療法，具體地，治療疼痛中的用途。