The present invention relates to compounds having dual pharmacological activity against sigma (σ) receptors and μ‑opioid receptors, and more specifically, to the compound containing such pharmacological activity, and to a method of preparing such compounds , Relates to pharmaceutical compositions containing them, and to their use in therapy, particularly for the treatment of pain.本發明涉及針對西格瑪(σ)受體及μ‑阿片樣物質受體具有雙重藥理學活性的化合物，且更具體地，涉及具有這種藥理學活性的呱嗪化合物，涉及製備這類化合物的方法，涉及包含它們的藥物組合物，以及涉及它們在治療中，特別地用於治療疼痛的用途。
