Christopher J. Helal;Patrick R. Verhoest;Jamison B. Tuttle;AMY B. DOUNAY
发明人:
AMY B. DOUNAY,Christopher J. Helal,Jamison B. Tuttle,Patrick R. Verhoest
申请号：
US13307140
公开号：
US20120142729A1
申请日:
2011.11.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to compounds 3-amino-1-hydroxy-2-oxo-1,2,3,4-tetrahydroquinoline-7-carbonitrile, 3-amino-1-hydroxy-7-(2-methoxyethoxy)-3,4-dihydroquinolin-2(1H)-one, and 3-amino-1-hydroxy-7-[(1S)-2-methoxy-1-methylethoxy]-3,4-dihydroquinolin-2(1H)-one, including racemic mixtures and resolved enantiomers thereof, to pharmaceutically acceptable salts thereof, and to the treatment of cognitive deficits associated with schizophrenia and other psychiatric, neurodegenerative and/or neurological disorders in mammals, including humans.
