The present invention provides methods for management fat accumulation in an adipocyte using compositions comprising a polymethoxylated flavone fraction of at least one of 5,6,7,3,4-pentamethoxyflavone (sinensetin) 5,6,7,8,3,4-hexamethoxyflavone (nobiletin) 5,6,7,8,4-pentamethoxyflavone (tangeretin) 5-hydroxy-6,7,8,3,4-pentamethoxyflavone (auranetin) 5-hydroxy-7,8,3,4-tetramethoxyflavone 5,7-dihydroxy-6,8,3,4-tetramethoxyflavone 5,7,8,3,4-pentamethoxyflavone 5,7,8,4-tetramethoxyflavone 3,5,6,7,8,3,4-heptamethoxyflavone 5-hydroxy-3,6,7,8,3,4-hexamethoxyflavone 5-hydroxy-6,7,8,4-tetramethoxyflavone 5,6,7,4-tetramethoxyflavone 7-hydroxy-3,5,6,8,3,4-hexamethoxyflavone or 7-hydroxy-3,5,6,3,4-pentamethoxyflavone. In certain embodiments, methods for preventing rebound weight gain in a subject who has experienced weight loss are provided.
