(S) N (3 (6 ISOPROPOXYPYRIDIN 3 YL) 1H INDAZOL 5 YL) 1 (2 (4 (4 (1 METHYL 1H 1 2 4 TRIAZOL 3 YL)PHENYL) 3 6 DIHYDROPYRIDIN 1(2H) YL) 2 OXOETHYL) 3 (METHYLTHIO)PYRROLIDINE 3 CARBOXAMIDE COMPOSITIONS FOR PHARMACEUTICAL PREPARATIONS

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专利权人:

发明人:

BAHL DEEPAK,LEE YUNG CHI,LEE ALFRED,MARINARO WILLIAM ANTHONY JR,ZHANG DAN,FENG TAO

申请号：

IN201717018841

公开号：

IN201717018841A

申请日:

2017.05.29

申请国别(地区):

IN

年份:

2017

代理人:

摘要：

The invention includes a granular composition comprising the active ingredient (S) N (3 (6 isopropoxypyridin 3 yl) 1H indazol 5 yl) 1 (2 (4 (4 (1 methyl 1H 1 2 4 triazol 3 yl)phenyl) 3 6 dihydropyridin 1(2H) yl) 2 oxoethyl) 3 (methylthio)pyrrolidine 3 carboxamide wherein a total amount of active ingredient comprises by weight % about 60 90% (S) N (3 (6 isopropoxypyridin 3 yl) 1H indazol 5 y1) 1 (2 (4 (4 (1 methyl 1H 1 2 4 triazol 3 yl)phenyl) 3 6 dihydropyridin 1(2H) yl) 2 oxoethyl) 3 (methylthio)pyrrolidine 3 carboxamide Form 1 HCl about 10 30% (S) N (3 (6 isopropoxypyridin 3 yl) 1H indazol 5 yl) 1 (2 (4 (4 (1 methyl 1H 1 2 4 triazol 3 yl)phenyl) 3 6 dihydropyridin 1(2H) yl) 2 oxoethyl) 3 (methylthio)pyrrolidine 3 carboxamide amorphous HCl and about 0 5% (S) N (3 (6 isopropoxypyridin 3 yl) 1H indazol 5 yl) 1 (2 (4 (4 (1 methyl 1H 1 2 4 triazol 3 yl)phenyl) 3 6 dihydropyridin 1(2H) yl) 2 oxoethyl) 3 (methylthio)pyrrolidine 3 carboxamide amorphous free base.

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