바흘, 디팍,리, 융치,리, 알프레드,마리나로, 윌리엄 안토니, 주니어,장, 단,펭, 타오
申请号：
KR1020177019669
公开号：
KR1020170094795A
申请日:
2015.12.14
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
(S) -N- (3- (6-isopropoxypyridin-3-yl) -1H-indazol- Yl) -2-oxoethyl) -3- (methylthio) pyridin-2-ylmethyl) Carboxamide, wherein the total amount of active ingredient is about 60-90% by weight of (S) -N- (3- (6-isopropoxypyridin-3-yl) -1H- Yl) -1- (2- (4- (4- (1-methyl-1H-1,2,4-triazol-3-yl) phenyl) -3,6-dihydropyridin- (S) -N- (3- (6-fluoropyridin-2-yl) -LH-indazol-5-yl) -1- (2- (4- (4- (1 -methyl- Yl) -2-oxoethyl) -3- (methylthio) pyrrolidine-3-carboxamide amorphous HCl, and about 0-5 (S) -N- (3- (6-isopropoxypyridin-3-yl) -1H-indazol- -1H-1,2,4-triazol-3-yl) phenyl) -3,6-dihydro Pyridin-l (2H) -yl) -2-oxoethyl) -3- (methylthio) pyrrolidine-3-carboxamide amorphous free base.본 발명은 유효 성분 (S)-N-(3-(6-이소프로폭시피리딘-3-일)-1H-인다졸-5-일)-1-(2-(4-(4-(1-메틸-1H-1,2,4-트리아졸-3-일)페닐)-3,6-디히드로피리딘-1(2H)-일)-2-옥소에틸)-3-(메틸티오)피롤리딘-3-카르복사미드를 포함하고, 여기서 유효 성분의 총량은 약 60-90 중량%의 (S)-N-(3-(6-이소프로폭시피리딘-3-일)-1H-인다졸-5-일)-1-(2-(4-(4-(1-메틸-1H-1,2,4-트리아졸-3-일)페닐)-3,6-디히드로피리딘-1(2H)-일)-2-옥소에틸)-3-(메틸티오)피롤리딘-3-카르복사미드 형태 1 HCl, 약 10-30 중량%의 (S)-N-(3-(6-이소프로폭시피리딘-3-일)-1H-인다졸-5-일)-1-(2-(4-(4-(1-메틸-1H-1,2,4-트리아졸-3-일)페닐)-3,6-디히드로피리딘-1(2H)-일)-2-옥소에틸)-3-(메틸티오)피롤리딘-3-카르복사미드 비결정질 HCl, 및 약 0-5 중량%의 (S)-N-(3-(6-이소프로폭시피리딘-3-일)-1H-인다졸-5-일)-1-(2-(4-(4-(1-메틸-1H-1,2,4-트리아졸-3-일)페닐)-3,6-디히드로피리딘-1(2H)-일)-2-옥소에틸)-3-(메틸티오)피롤리딘-3-카르복사미드 비결정질 유리 염기를 포함하는 것인 과립 조성물을 포함한다.
