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Cyanomethylpyrazole carboxamides as Janus kinase inhibitors
- 专利权人:
- MERCK SHARP & DOHME CORP.
- 发明人:
- BRUBAKER, Jason,CHILDERS, Matthew Lloyd,CHRISTOPHER, Matthew,CLOSE, Joshua,KATZ, Jason David,JUNG, Joon,PETERSON, Scott,SILIPHAIVANH, Phieng,SIU, Tony,SMITH, Graham Frank,TORRES, Luis,WOO, Hyun Chong
- 申请号:
- ES12834379
- 公开号:
- ES2670878T3
- 申请日:
- 2012.09.21
- 申请国别(地区):
- ES
- 年份:
- 2018
- 代理人:
- 摘要:
- A compound of formula I or a pharmaceutically acceptable salt or a stereoisomer thereof: ** Formula ** each of Ra and R4 is independently selected from hydrogen and C1-4 alkyl; A is selected from aryl and heteroaryl; n is independently 0, 1, 2, 3 or 4; p is 2 or 3; X is independently selected from C, N, O and S; each of R3 and R7 is independently selected from hydrogen, halogen, C1-10 alkyl, C2-10 alkenyl, C1-10 heteroalkyl, C0-10 arylalkylC0-10 alkyl, C3-8 cycloalkylC0-10 alkyl, heteroarylC0- alkyl 10, heterocycloalkyl (C3-8) C0-10 alkyl, and wherein each of R3 and R7 are independently substituted with 0, 1, 2, 3 or 4 substituents R5a; R5a is selected from: halogen, C1-10 alkyl (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, C1-10 heteroalkyl 0-1 (carbonyl) 0-1 C0-10 alkyl, C2 alkenyl 10 (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, C0-10 aryl (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, C2-10 alkenyl (oxy) 0-1 ( carbonyl) 0-1 C0-10 alkyl, C2-10 aryl alkyl (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, C3-8 cycloalkyl C0-10 alkyl (oxy) 0-1 (carbonyl) 0-1 alkyl C0-10, heteroarylalkyl C0-10 (oxy) 0-1 (carbonyl) 0-1alkyl C0-10, heterocycloalkyl (C3-8) alkyl C0-10 (oxy) 0-1 (carbonyl) 0-1alkyl C0-10, C1-10 alkyl (carbonyl) 0-1oxyC0-10 alkyl, C1-10 heteroalkyl (carbonyl) 0-1oxyC0-10 alkyl, C2-10 alkenyl (carbonyl) 0-1oxyC0-10 alkyl, C1-10 heteroalkyl (carbonyl ) 0-1oxy C0-10 alkyl, aryl C0-10 alkyl (carbonyl) 0-1oxy alkyl C0-10, cycloalkyl (C3-8) alkyl C0-10 (carbonyl) 0-1oxy alkyl C0-10, heteroarylalkyl C0-10 (carbonyl) 0-1oxyalkyl C0-10, heterocycloalkyl (C3-8) alkyl C0-10 (carbonyl) 0-1oxy alkyl C0-10, (alkyl (C0-10 )) 1-2-aminocarbonyloxy, heteroalkyl (C0-10) aminocarbonyloxy, arylalkyl (C0-10) aminocarbonyloxy, cycloalkyl (C3-8) alkyl (C0-10) aminocarbonyloxy, heteroarylalkyl (C0-10) aminocarbonyloxy, heterocycloalkyl (C3-8) (C0-10) aminocarbonyloxy, C0-10 alkyl amino (oxy) 0-1carbonylalkyl C0-10, heteroalkyl (C0-10) amino (oxy) 0-1carbonylalkylC0-10 alkyl, C3-8 alkyl C0-10 amino ( oxy) 0-1carbonyl
- 来源网站:
- 中国工程科技知识中心
- 来源网址:
- http://www.ckcest.cn/home/