CHA MI YOUNG,KANG SEOK JONG,KIM MI RA,LEE JU YEON,JEON JI YOUNG,JO MYOUNG GI,KWAK EUN JOO,LEE KWANG OK,HA TAE HEE,SUH KWEE HYUN,KIM MAENG SUP
申请号：
NZ62770911
公开号：
NZ627709A
申请日:
2011.06.20
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed are furo[3,2-d]pyrimidine derivatives of formula (I) or a pharmaceutically acceptable salt thereof, wherein, W is O X is O, NH, S, SO or SO2 Y is hydrogen, halogen, alkyl or alkoxy A and B are each independently hydrogen atom, halogen atom, or di(alkyl)aminomethyl Z is optionally substituted aryl or optionally substituted heteroaryl optionally, the alkyl is partially unsaturated or has a cycloalkyl moiety. Representative compounds include N-(3-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((4-morpholinophenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((4-((dimethylamino)methyl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((4-((4-(dimethylamino)piperidin-1-yl)methyl)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((3-fluoro-4-(1-methylpiperazin-4-l)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((4-(2-dimethylamino)ethyl)amino)-3-fluorophenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-((2-((3-fluoro-4-((1-methylpiperidin-4-yl)amino)phenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide, N-(3-(2-(3-methoxy-4-(4-methyl-piperazin-1-yl)-phenylamino)-furo[3,2-d]pyrimidin-4-yloxy)-phenyl)-acrylamide and N-(3-((2-((4-sulfamoylphenyl)amino)furo[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide. Further disclosed is a pharmaceutical composition for preventing or treating cancers, tumours, inflammatory diseases, autoimmune diseases, or immunologically mediated diseases which comprises the compound of formula (I) as defined above or its pharmaceutically acceptable salt as an active ingredient.
