BRUBAKER, Jason,DINSMORE, Christopher J.,HOFFMAN, Dawn Marie,JUNG, Joon,LIU, Duan,PETERSON, Scott,SIU, Tony,TORRES, Luis E.,ZHANG, Hongjun,WEI, Zhongyong,SHI, Feng
申请号：
ES12833410
公开号：
ES2640911T3
申请日:
2012.09.21
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula I or a pharmaceutically acceptable salt or stereoisomer thereof: each of Ra and R4 is independently selected from hydrogen and C1-4 alkyl； A is selected from aryl, and heteroaryl； n is 0, 1,2, 3, or 4； p is 2, 3, or 4； each of R2 and R7 is independently selected from hydrogen, halogen, C1-10 alkyl, C2-10 alkenyl, C1-10 heteroalkyl, C0-10 arylalkylC0-10 alkyl, C3-8 cycloalkylC0-10 alkyl, heteroarylalkylC0- 10, heterocycloalkyl (C3-8) alkyl C0-10, and wherein each of R2 and R7 is independently substituted with 0, 1,2, 3 or 4 substituents R5a； R5a is selected from: halogen, C1-10 alkyl (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, C1-10 heteroalkyl 0-1 (carbonyl) 0-1 C0-10 alkyl, C2 alkenyl 10 (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, C0-10 aryl 0-1 alkyl (carbonyl) 0-1 C0-10 alkyl, C2-10 aryl alkenyl (oxy) 0-1 ( carbonyl) 0-1 C0-10 alkyl, C2-10 aryl alkyl (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, C3-8 cycloalkyl C0-10 alkyl (oxy) 0-1 (carbonyl) 0-1 alkyl C0-10, heteroarylalkyl C0-10 (oxy) 0-1 (carbonyl) 0-1alkyl C0-10, heterocycloalkyl (C3-8) alkyl C0-10 (oxy) 0-1 (carbonyl) 0-1alkyl C0-10, C1-10 alkyl (carbonyl) 0-1oxy C0-10 alkyl, C1-10 heteroalkyl (carbonyl) 0-1oxy C0-10 alkyl, C2-10 alkenyl (carbonyl) 0-1oxy C0-10 alkyl, C1-10 heteroalkyl ( carbonyl) 0-1oxy C0-10 alkyl, C0-10 aryl alkyl (carbonyl) 0-1oxy C0-10 alkyl, cycloalkyl (C3-8) C0-10 alkyl (carbonyl) 0-1oxy C0-10 alkyl, heteroarylalkyl C0- 10 (carbonyl) 0-1oxyalkyl C0-10, heterocycloalkyl (C3-8) alkyl C0-10 (carbonyl) 0-1oxy C0-10 alkyl, ((C0-10) alkyl) 1-2 aminocarbonyloxy, heteroalkyl (C0-10) aminocarbonyloxy, arylalkyl (C0-10) aminocarbonyloxy, cycloalkyl (C3-8) alkyl (C0-10) aminocarbonyloxy, heteroarylalkyl (C0-10) aminocarbonyloxy, heterocycloalkyl (C3-8) alkyl (C0- 10) aminocarbonyloxy, C0-10 alkyl amino (oxy) 0-1 (carbonyl) 0-1 C2-10 alkenyl, C1-10 alkyl amino (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, heteroalkyl ( C0-10) amin (oxy) 0-1 (carbonyl) 0-1 C0-10 alkyl, C3-8 cycloalkyl C0-10 alkyl amino
