BOSCH H. WILLIAM,CALLAHAN MATTHEW,MEISER FELIX,NORRET MARCK,RUSSELL ADRIAN
申请号：
NZ62943813
公开号：
NZ629438A
申请日:
2013.02.28
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed herein is a method for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 &mu；m； and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 &mu；m and 20 &mu；m. Also disclosed are inhalable compositions produced by the method.
