Bosch, H. William,Callahan, Matthew,Meiser, Felix,Norret, Marck,Russell, Adrian
申请号：
NZ72295213
公开号：
NZ722952A
申请日:
2013.02.28
申请国别(地区):
NZ
年份:
2018
代理人:
摘要：
Disclosed herein is a method for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 μm； and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 μm and 20 μm. Also disclosed are inhalable compositions produced by the method. The pharmaceutically active agent in the pharmaceutically-active composition has a concentration of from about 0.1% to about 40% by weight.
